Episode 14 ยท Lucy & Ellie Podcast

De-Extinction

Jurassic Park was supposed to be a warning. Instead, we watched it and took notes.

๐ŸŽ Apple Podcasts ๐ŸŽต Spotify ๐Ÿ“ฆ Amazon Music ๐ŸŒ lucyandellie.ai
โ† All Episodes

The Science Is Real and Moving Fast

Colossal Biosciences, founded in 2021, has a single audacious goal: resurrect the woolly mammoth. Not a theme park attraction โ€” a living, breathing, cold-adapted elephant that can walk across Siberia and restore the lost grassland ecosystems that once held the permafrost together. They have funding. They have a timeline. They have CRISPR.

Australia's Thylacine Integrated Genetic Restoration Research Lab (TIGRR) is working on the Tasmanian tiger โ€” extinct since 1936, but with preserved DNA available. The passenger pigeon project, run by Revive & Restore, is editing living band-tailed pigeon genomes to re-express lost traits. De-extinction isn't theoretical. It's a race.

How CRISPR Makes It Possible

The breakthrough enabling all of this is CRISPR-Cas9 โ€” a molecular tool that allows scientists to edit DNA with surgical precision. Where traditional cloning requires an intact living cell, CRISPR allows researchers to take a closely related living species and edit its genome to express the traits of the extinct one.

For the mammoth, this means taking Asian elephant cells โ€” the mammoth's closest living relative โ€” and editing in cold-adaptation genes recovered from frozen mammoth specimens. The result won't be a perfect mammoth. It'll be a hybrid. But it will carry the ecological function of the animal that disappeared.

"The question was never whether we could bring them back. The question is whether the world they return to is one they can survive."

Should We Do It? The Ethical Minefield

Even scientists who support de-extinction have serious reservations. Bringing back a species requires more than genetics โ€” it requires habitat, prey, social structure, and learned behaviour. A mammoth raised without other mammoths has no mammoth culture. A thylacine with no parents to teach it hunting is ecologically orphaned from the moment it's born.

And then there's the conservation funding question. Every dollar spent on a spectacular resurrection is a dollar not spent on the thousands of species quietly sliding toward extinction right now. De-extinction is science's most photogenic project. Whether it's its most useful one is a harder conversation.

The Ecological Case For It

Lucy and Ellie don't land cleanly on one side of this debate. That's the point. Listen and decide where you stand.